Table 1 Clinicopathological characteristics of the study cohorts.
Type | Internal Development Cohort | Internal Validation Cohort | External Validation Cohort | ||||
|---|---|---|---|---|---|---|---|
Dataset | KSH-DEV | KSH-GAT | KSH-GGT | KSH-GCB | KSH-STO | TCGA-STAD | |
Acquisition period | 2011–2014 | 2011–2014 | 2016–2020 | 2016–2020 | 2022–2023 | 2013–2023 | - |
Patients included in this study | 24 | 708 | 285 | 285 | 181 | 854 | 347 |
EBV-Positive | 24 | 98 | 18 | 18 | 15 | 20 | 26 |
EBV-Negative | 0 | 610 | 267 | 267 | 166 | 834 | 321 |
Age, years | 61.13 | 62.98 | 64.57 | 64.57 | 67.20 | 64.37 | 64.05 |
Sex | |||||||
Male | 22 | 504 | 185 | 185 | 124 | 542 | 225 |
Female | 2 | 204 | 100 | 100 | 57 | 312 | 112 |
Unknown | 0 | 0 | 0 | 0 | 0 | 0 | 10 |
Histologic type | |||||||
Papillary adenocarcinoma | 0 | 1 | 0 | 0 | 0 | 8 | 7 |
Tubular adenocarcinoma | 24 | 629 | 258 | 258 | 161 | 554 | 66 |
Well differentiated | 0 | 210 | 130 | 130 | 21 | 85 | 0 |
Moderately differentiated | 8 | 191 | 91 | 91 | 55 | 261 | 0 |
Poorly differentiated | 16 | 228 | 37 | 37 | 85 | 208 | 0 |
Unknown | 0 | 0 | 0 | 0 | 0 | 0 | 66 |
Mucinous adenocarcinoma | 0 | 4 | 0 | 0 | 1 | 10 | 18 |
Poorly cohesive carcinoma | 0 | 21 | 2 | 2 | 10 | 198 | 54 |
Signet ring cell carcinoma | 0 | 52 | 15 | 15 | 7 | 3 | 14 |
Adenosquamous carcinoma | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
Medullary carcinoma | 0 | 1 | 9 | 9 | 0 | 3 | 0 |
Undifferentiated carcinoma | 0 | 0 | 0 | 0 | 0 | 3 | 0 |
Mixed | 0 | 0 | 0 | 0 | 2 | 71 | 0 |
Unknown | 0 | 0 | 1 | 1 | 0 | 2 | 178 |
Digital Slide Scanner | Leica Aperio AT2 | Leica Aperio AT2 | Leica Aperio AT2 | Leica Aperio GT450 | Leica Aperio GT450 | Leica Aperio GT450 | Various |
Magnification | 40x | 40x | 40x | 40x | 40x | 40x | 20x – 40x |
Resolution | 0.2521µm2 | 0.2521µm2 | 0.2521µm2 | 0.2635µm2 | 0.2635µm2 | 0.2635µm2 | 0.2325µm2 ~ 0.5005µm2 |
Sample Type | WSI | TMA | Biopsy | Biopsy | Biopsy | WSI | WSI |
