Table 3 Plasma concentrations of endothelium activation markers before and after LPS infusion.

From: A randomized placebo-controlled trial in healthy volunteers examining the effects of acetaminophen and NO-acetaminophen NCX 701 in human endotoxemia

   

Basal concentrations

Peak concentrations

Pharmacodynamic Marker

Treatment

n

Mean (SD)

Mean (SD)

VWF (U/dl)

Placebo

10

106 (44)

420 (126)

 

Acetaminophen

10

98 (38)

314 (112)

 

NCX701 (1 g)

10

94 (28)

293 (80) *

 

NCX701 (2 g)

10

116 (45)

330 (144) **

Soluble E-Selectin (ng/ml)

Placebo

10

34 (15)

171 (96)

 

Acetaminophen

10

41 (16)

163 (63)

 

NCX701 (1 g)

10

34 (16)

138 (48)

 

NCX701 (2 g)

10

35 (12)

188 (99)

VCAM-1 (ng/ml)

Placebo

10

577 (139)

663 (160)

 

Acetaminophen

10

466 (126)

553 (129)

 

NCX701 (1 g)

10

504 (109)

643 (81)

 

NCX701 (2 g)

10

549 (102)

665 (125)

  1. * p = 0.02 for placebo vs. NCX701 (1 g).
  2. ** p = 0.047 for placebo vs. NCX701 (2 g).
Back to article page