Fig. 11 | Scientific Reports

Fig. 11

From: Novel curcumin nanocarrier for targeting drug delivery of mitochondria proves efficacy in in vivo experiments on hepatocellular carcinoma mice models

Fig. 11

Real time PCR analysis. RNA expression changes of bax, bcl2, p21, p53, xiaop, rb1 in the liver tissues of normal BALB/c mice (A) and curcumin treated HCC model (B). TDC led to the dramatically increased expression of p53, especially in positive tumor samples (P value < 0.0001). The bcl2, xiaop, rb1, and p21 were respectively the most declined genes (P value < 0.0001) by TDC in HCC positives versus healthy samples. The bax was significantly (P value < 0.001) increased by TDC in both cancerous and healthy samples. Data are indicated as Mean ± SEM, N = 3 mice per group. Different lowercase letters above the bars indicate significant differences between treatments.

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