Fig. 7 | Scientific Reports

Fig. 7

From: Novel curcumin nanocarrier for targeting drug delivery of mitochondria proves efficacy in in vivo experiments on hepatocellular carcinoma mice models

Fig. 7

Flow cytometric analysis of cell cycle and Apoptosis assay. (A) Flow cytometric analysis of cell cycle. In the HCC samples, all curcumin treatments induced remarkably elevated cells population in the sub-G1 phase (P-value < 0.0001), meanwhile TDC had the most impact on the increased cells population in the sub-G1. N = 3 mice per group. (B) Apoptosis assay. Induction of apoptosis by all curcumin carriers were significantly higher compared with their untreated controls. The rate of increased apoptosis by TDC is higher than other treatments, especially in the HCC tumorized mice (P value < 0.0001), graphs are shown as Mean ± SEM (C). N = 3 mice per group. Different lowercase letters above the bars indicate significant differences between treatments.

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