Fig. 8 | Scientific Reports

Fig. 8

From: Novel curcumin nanocarrier for targeting drug delivery of mitochondria proves efficacy in in vivo experiments on hepatocellular carcinoma mice models

Fig. 8

ROS flow cytometry analysis. ROS levels in the isolated hepatocytes from the treated healthy (A) and HCC model BALB/c mice (B) were examined by H2DCFDA in a flow cytometry instrument. Obtained data from the flow cytometry were analyzed by Flowing software (Version 2.4.1). H2O2 were applied as a positive control. Graphs are presented as Mean ± SEM (C) separately for healthy (negative tumor) and HCC model BALB/c mice (positive tumor). In the healthy study group TDC, DC, and FC treated samples were significantly (P value < 0.0001, < 0.001, 0.01, respectively) elevated. The increased rate of ROS influenced by curcumin treatments is higher in HCC models compared with the healthy samples. Hepatocytes of all treated HCC mice compared with its untreated control had significantly (P value < 0.0001) raised amount of ROS, which TDC among others had the most significant effect. Different lowercase letters above the bars indicate significant differences between treatments.

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