Table 1 Baseline characteristics of patients with NA-RAO with/without RNF213 p.Arg4810Lys.
From: RNF213 c.14429G > A (p.Arg4810Lys) is associated with non-arteritic retinal artery occlusion
NA-RAO (N = 28) | RNF213 p.Arg4810Lys | Wild type (n = 25) | P-value | |
|---|---|---|---|---|
Variant (n = 3) | ||||
Mean age (range) | 66 ± 13 (40–84) | 59 ± 17 (40–71) | 67 ± 12 (38–84) | 0.248 |
Sex (female) | 21 (76%) | 2(67%) | 19(76%) | 0.736 |
Occlusion side (left) | 14 (52%) | 1(33%) | 13(52%) | 0.371 |
Hypertension | 20 (76%) | 1(33%) | 19(76%) | 0.131 |
Diabetes mellitus | 10 (40%) | 0(0%) | 10(40%) | 0.185 |
Dyslipidaemia | 16 (56%) | 2(67%) | 14(56%) | 0.736 |
Atrial fibrillation | 6 (24%) | 0(0%) | 6(24%) | 0.357 |
Previous CI | 5 (16%) | 1(33%) | 4(16%) | 0.477 |
Previous CAD | 3 (12%) | 0(0%) | 3(12%) | 0.543 |
Family history of stroke | 13 (44%) | 2(67%) | 11(44%) | 0.476 |
Smoking (current or past) | 6 (20%) | 1(33%) | 5(20%) | 0.888 |
Haematocrit, % | 40.9 ± 5.1 | 40.2 ± 6.5 | 41.1 ± 4.53 | 0.780 |
Triglyceride, mg/dL | 152 ± 108 | 117 ± 63 | 156 ± 112 | 0.834 |
LDL-cholesterol, mg/dL | 122 ± 30 | 114 ± 5 | 122 ± 31 | 0.726 |
HbA1c, % (SD) | 6.7 ± 2.0 | 5.4 ± 0.2 | 6.4 ± 1.2 | 0.010* |
GFR, mL/min/1.73m2 | 65.4 ± 19.8 | 64.1 ± 22.4 | 65.6 ± 20.0 | 0.889 |
Body mass index, kg/m2 | 23.4 ± 2.8 | 24.7 ± 3.0 | 23.2 ± 2.8 | 0.351 |
Co-incident CI | 12 (44%) | 1 (33%) | 11 (44%) | 0.736 |
Only ICAS | 5 (18%) | 1 (33%) | 4 (16%) | 0.459 |
Only ECAS | 3 (11%) | 0 (0%) | 3 (12%) | 0.999 |
ICAS + ECAS | 5 (18%) | 1 (33%) | 4 (16%) | 0.459 |
IMT (affected side), mm | 2.7 ± 1.6 | 2.1 ± 1.3 | 2.7 ± 1.6 | 0.524 |
IMT (unaffected side), mm | 2.5 ± 1.4 | 1.6 ± 0.9 | 2.5 ± 1.3 | 0.314 |
