Table 3 Associations of pubertal development, body size, and age at menarche with DNA-methylation biomarker of pubertal age across three cohorts.

From: Salivary DNA methylation and pubertal development in adolescents

Texas Twin Project (TTP)

 

DNAm PubertalAge

DNAm PubertalAgeAccel

Girls

β

SE

p

R2

β

SE

p

R2

Pubertal development

0.67

0.06

< 0.001

0.45

0.11

0.08

0.16

0.01

BMI

0.28

0.09

0.003

0.07

0.27

0.08

0.001

0.06

Height

0.59

0.06

< 0.001

0.36

0.08

0.07

0.26

0.01

Age at menarche

0.04

0.16

0.82

0.00

− 0.23

0.10

0.02

0.06

Boys

        

Pubertal development

0.67

0.06

< 0.001

0.45

0.04

0.08

0.62

0.00

BMI

0.19

0.11

0.10

0.02

0.01

0.10

0.90

0.00

Height

0.78

0.05

< 0.001

0.63

− 0.07

0.06

0.26

0.00

Future of Families and Child Well-Being Study (FFCW)

 

DNAm PubertalAge

DNAm PubertalAgeAccel

Girls

β

SE

p

R2

β

SE

p

R2

Pubertal development

0.09

0.03

0.008

0.01

0.06

0.03

0.094

0.00

BMI

0.16

0.03

< 0.001

0.02

0.14

0.03

< 0.001

0.02

Height

0.01

0.03

0.76

0.00

0.02

0.03

0.55

0.00

Age at menarche

− 0.13

0.04

0.005

0.01

− 0.13

0.04

0.003

0.01

Boys

        

Pubertal development

− 0.05

0.06

0.37

0.00

− 0.06

0.06

0.29

0.00

BMI

0.06

0.03

0.06

0.00

0.06

0.03

0.01

0.00

Height

0.11

0.03

0.001

0.01

0.08

0.03

0.01

0.01

German Twin Family Panel (TwinLife)

 

DNAm PubertalAge

DNAm PubertalAgeAccel

Girls

β

SE

p

R2

β

SE

p

R2

Pubertal development

0.31

0.14

0.03

0.03

0.17

0.08

0.04

0.03

BMI

0.35

0.13

0.007

0.03

0.19

0.07

0.007

0.04

Height

0.08

0.11

0.49

0.00

0.05

0.06

0.48

0.00

Age at menarche

− 0.22

0.08

0.004

0.03

− 0.17

0.05

0.001

0.03

Boys

        

Pubertal development

0.11

0.15

0.46

0.00

0.06

0.09

0.55

0.00

BMI

0.01

0.13

0.94

0.00

0.01

0.08

0.86

0.00

Height

0.23

0.14

0.11

0.02

0.14

0.08

0.11

0.02