Fig. 3 | Scientific Reports

Fig. 3

From: HMMR mediates progression of nasopharyngeal carcinoma by inhibiting FAM83D ubiquitination and activating beta-catenin signaling pathway

Fig. 3

The ability of NPC cells to progress in vitro is influenced by HMMR. (A) Decreasing the expression of HMMR reduces the number of SUNE1 cell colonies. (B) Increasing the expression of HMMR elevates the number of CNE2 cell colonies. (C) Reducing HMMR expression decreases the percentage of Edu-positive SUNE1 cells. (D) Enhancing HMMR expression increases the percentage of Edu-positive CNE2 cells. (E) Downregulated HMMR expression suppresses the migration ability of SUNE1 cells as shown by wound healing assay. (F) Upregulated HMMR expression promotes the migration ability of CNE2 cells as demonstrated by wound healing assay. (G) Downregulated HMMR expression suppresses the migration and invasion abilities of SUNE1 cells as shown by transwell assay. (H) Upregulated HMMR expression promotes the migration and invasion abilities of CNE2 cells as demonstrated by transwell assay. (I) Modulating HMMR expression affects the expression of EMT-related biomarkers in SUNE1 cells as evidenced by immunofluorescence and western blot assays. (J) Modulating HMMR expression affects the expression of EMT-related biomarkers in CNE2 cells as evidenced by immunofluorescence and western blot assays.

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