Fig. 2
Subclustering of epithelial cells. (a) The heatmap displays the most significantly differentially expressed genes in epithelial cells across different groups. (b) UMAP plot of 38,541 single cells from epithelial cells used for subclustering. (c) The proportions of identified epithelial cell populations in each tissue type. (d) UMAP plot of 7453 single cells from myoepithelial cells used for subclustering. (e) Rain cloud plot showing the CNV scores across different myoepithelial subsets. (f) The paired boxplot displays the differences in GSVA scores of myoepithelial subsets’ characteristics between Normol and IMPA in the external bulk dataset. (g) Heatmap showing GSVA scores for various signaling pathways across different myoepithelial subsets. (h) Representative images of multiplex immunohistochemistry (mIHC) showing the expression of CK14 (red) and MYLK (green) in PA sections; scale bar = 100 μm.
