Table 6 The expression of DN B cells in different populations.

From: Decreased IgD- CD27- double negative B cells in Sjögren’s disease correlated with disease activity index

Health status

Phenotype

Expression

Correlations

Possible role

References

Autoimmune diseases

SLE

CD19 + CD27– lgD–

Increased in PB

With the incidence of LN

Autoimmunogenic

28

RA

CD19 + CD27– lgD–

Increased in PB

No correlation with disease activity scores

Precursor of ASCs

25

SSc

CD19 + CD27– lgD–

Increased in PB

With presence of ILD

Suppress humoral response

13

MS

CD19 + CD27– lgD–

Increased in PB and CSF

With the presence of brain inflammatoion

Similar to SM B cells

12,23

IBD

CD19 + CD27– lgD–

Decreased in PB

Independent of severity of disease and treatment

Antibacterial immunity

26

Aging

CD19 + CD27– lgD–

Increased in PB

Age-associated

Chronic inflammation

11

Infection

COVID-19

CD19+ CD27 − CD38− CD24− IgD − CD11c+ CD21−

Increased in PB

With poor prognosis

Autoimmunogenic and Antipathogenic

27

Malaria

CD19+ CD27– CD21−

Increased in PB

Affinity maturation

Antipathogenic

29

Cancers NSCLC

CD19+ CD27– lgD–

Increased in tumor tissue

Inversely with CD27 + IgD − B cells

Immunosuppressive

24

  1. DN: double negative, SLE: systemic lupus erythematosus, PB: peripheral blood, LN: lupus nephritis, RA: rheumatoid arthritis, ASCs: antibody-secreting cells, SSc: systemic sclerosis, ILD: interstitial lung disease, MS: multiple sclerosis, CSF: cerebrospinal fluid, SM: switched memory, IBD: inflammatory bowel disease, NSCLC: non-small cell lung cancer.
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