Fig. 5 | Scientific Reports

Fig. 5

From: Integrated machine learning identifies biomarkers for bilirubin-induced Alzheimer’s disease-like lesions in neonates and adults

Fig. 5

WGCNA identifies AD- and immune cell–related gene modules. (A) (A) Proportions of 28 immune cell types in control and AD groups. (B) Scale-free network construction with soft-threshold power = 6 (scale-free R² = 0.85). ( C) Module–trait heatmap showing correlations between gene modules, AD, and immune cells. (D) Scatter plots of grey60, pink, tan, saddlebrown, and lightcyan modules, showing strong positive correlations with AD. (E, F) GO and KEGG enrichment analyses of module genes. (G) Correlation between GS and MM in activated dendritic cells, effector memory CD8⁺ T cells, myeloid-derived suppressor cells, natural killer T cells, neutrophils, and plasmacytoid dendritic cells.

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