Fig. 1 | Scientific Reports

Fig. 1

From: CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition

Fig. 1

(A) Chemical structure of CH7450924. (B) (C) Overall structures of human KEAP1 in complex with CH7450924 and NRF2 ETGE peptide shown as diagrams in light-pink (PDB ID: 9M24) and pale-cyan (PDB ID: 5WFV), respectively. CH7450924, ETGE peptide, and interacting residues defined as having at least one non-hydrogen atom within 4.2 Å of the respective ligand, are shown as colored stick models (C, magenta/light-pink in Fig. 1B or marine/cyan in Fig. 1C; O, red; N, blue; F, pale-cyan; Cl, green). Common amino acid residues involved in binding both CH7450924 and the ETGE peptide are highlighted with a yellow surface representation. (D) KEAP1-NRF2 interaction inhibitory activity. Data are represented as mean + SD of three measurement points.

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