Fig. 2 | Scientific Reports

Fig. 2

From: CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition

Fig. 2

Effects of CH7450924 in MODS model induced by intraperitoneal LPS injection. (A) 72-h survival rate. CH7450924 was administered at 10 mg/kg twice a day before and after LPS injection. (B) IL-6, IL-1β, and TNFα concentration in plasma, (C) mRNA expression of IL-6, IL-1β, and TNFα in the kidney and (D) liver, (E) plasma creatinine and BUN levels, (F) mRNA expression of KIM-1 and NGAL in the kidney, and (G) plasma AST, ALT, and T-BIL levels. CH7450924 was administered at 20 mg/kg before LPS injection. The actual values are represented as dots, and the bars represent mean ± SE (n = 8). #p < 0.05, significant difference between NC and DC (Student’s t-test). *p < 0.05, significant difference between DC and CH7450924 (Student’s t-test). NC; Normal control, DC; Disease control, CH0924; CH7450924.

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