Fig. 4

Effects of CH7450924 on lung injury in MODS model induced by intratracheal LPS injection. (A) mRNA expression of IL-6, IL-1β in the lung, (B) lung wet weight, (C) representative HE-stained lung sections from NC, DC, and CH0924 (20 mg/kg) groups, (D) semi-quantitative analysis of neutrophil infiltration of alveoli and thickening of alveolar wall, (E) mRNA expression of SFTPC in lung, and (F) SpO₂ monitored using infrared pulse oximetry. CH7450924 was administered at 5, 10, or 20 mg/kg twice a day before and after LPS injection. The actual values are represented as dots, and the bars represent mean ± SE (NC: n = 3 or 4, others: n = 8 or 9). *p < 0.05, significant difference versus vehicle-treated LPS mice (Student’s t-test). #p < 0.05, significant difference between NC and DC (Student’s t-test). *p < 0.05, significant difference between DC and CH7450924 (William’s t-test). BR, Bronchiole, NC; Normal control, DC; Disease control, CH0924; CH7450924.