Table 1 The in vitro EC50 values of CH7450924 for relative NQO1 mRNA expression in cells.

From: CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition

Cell line (Species)

EC50 (nmol/L)

293 (Human)

2.5 ± 0.1

COS-7 (Monkey)

2.9 ± 0.2

NRK-52E (Rat)

4.0 ± 0.3

Mes13 (Mouse)

4.8 ± 0.2

  1. Values are expressed as mean ± SE from three independent experiments.
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