Table 2 Linear regression models of baseline level of depression (MADRS score) among people living with dementia in the HOMESIDE study by each of (i) stage, (ii) type and (iii) severity of dementia, iv) country of residence and level of depression (MADRS score) (N = 376).

From: Relationship between dementia diagnostic characteristics and severity of depressive symptoms in a cross-sectional analysis of HOMESIDE baseline data

 

Unadjusted analysis

Adjusted analysis

Mean difference

95% CI

P value

Mean difference

95% CI

P value

Stage of dementia*

Early

Reference

Reference

Reference

Reference

Reference

Reference

Late

− 1.16

− 3.18, 0.86

0.258

− 0.86

− 3.74, 2.03

0.560

Type of dementia†

Alzheimer’s disease and related dementias

Reference

Reference

Reference

Reference

Reference

Reference

Vascular and mixed dementias

0.04

− 1.95, 2.02

0.972

0.27

− 1.68, 2.22

0.785

Other dementia types

− 0.61

− 2.65, 1.43

0.559

− 1.26

− 3.27, 0.75

0.219

Severity of dementia‡

Mild dementia

Reference

Reference

Reference

Reference

Reference

Reference

Mild-moderate dementia

0.16

− 2.18, 2.50

0.895

− 0.05

− 2.30, 2.20

0.967

Moderate dementia

0.51

− 1.74, 2.77

0.656

0.51

− 1.69, 2.72

0.648

Severe dementia

3.59

1.38, 5.81

0.002

3.78

1.60, 5.96

0.001

Country of residence§

Australia

Reference

Reference

Reference

Reference

Reference

Reference

United Kingdom

− 3.28

− 5.38, − 1.18

0.002

− 2.41

− 4.49, − 0.34

0.023

Germany

− 2.23

− 4.40, − 0.06

0.044

− 2.51

− 4.63, − 0.40

0.020

Norway

− 4.89

− 7.41, − 2.37

 < 0.001

− 4.93

− 7.39, − 2.47

 < 0.001

Poland

1.48

− 1.29, 4.24

0.295

1.15

− 1.71, 4.02

0.428

  1. CI, confidence interval.
  2. *Early-onset and late-onset dementia consisted of participants with any form of dementia in people under the age of 65 and aged 65 and older, respectively. The adjusted model included study site, confounders (age, sex, education and occupation of the person with dementia), prognostic characteristics of the outcome (caregiver’s depression, marital status of the person with dementia, length of time with dementia).
  3. †Alzheimer’s disease and related dementias consisted of participants with Alzheimer’s disease, Frontotemporal dementia, Lewy body disease. Vascular and mixed dementias consisted of participants with vascular or mixed dementia, while Other dementia types consisted of other or unknown dementia. The adjusted model included study site, confounders (age, sex, education and occupation of the person with dementia), prognostic characteristics of the outcome (caregiver’s depression, marital status of the person with dementia, length of time with dementia).
  4. ‡The results of the Wald test suggest there were differences in severity of dementia. The adjusted model included study site, confounders (age, sex, education and occupation of the person with dementia), prognostic characteristics of the outcome (caregiver’s depression, marital status of the person with dementia, length of time with dementia).
  5. §The results of the Wald test suggest there were differences in countries. The adjusted model included the caregiver’s depression, marital status of the person with dementia, length of time with dementia.
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