Fig. 4 | Scientific Reports

Fig. 4

From: Deubiquitinating enzyme USP42 promotes breast cancer progression by inhibiting JNK/p38-mediated apoptosis

Fig. 4

USP42 downregulation increases apoptosis and regulates JNK and p38 phosphorylation in breast cancer cells. (A, B) Flow cytometric analysis of apoptotic cell numbers following USP42 downregulation in MCF-7 (A) and MDA-MB-231 (B) cells. (C) Western blot analysis of cleaved-caspase3, Bcl-2 and Bax protein levels in MCF-7 and MDA-MB-231 cells. β-actin served as an internal reference. (D) Western blotting analysis of p-p38, p38, JNK and p-JNK protein expression in MCF-7 and MDA-MB-231 cells. β-actin served as an internal reference.

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