Table 3 Univariable association of EEG biomarkers and DAT uptakes with neuropsychiatric symptoms.

From: Implication of dopamine transporter and electroencephalography biomarkers in dementia with lewy bodies

  

Fluctuation

Visual hallucination

RBD

OR (95% CI)

P

Q

OR (95% CI)

P

Q

OR (95% CI)

P

Q

EEG biomarker

PDR frequency

0.93 (0.67–1.28)

0.639

0.639

0.79 (0.54–1.16)

0.223

0.360

0.70 (0.48–1.02)

0.064

0.671

 

Frontal TBR

1.81 (1.12–2.93)

0.016

0.037

1.64 (0.92–2.91)

0.091

0.217

1.19 (0.71–1.99)

0.512

0.671

 

Temporal TBR

1.79 (1.17–2.72)

0.007

0.032

1.54 (0.93–2.53)

0.093

0.217

1.25 (0.80–1.96)

0.325

0.671

 

Central TBR

1.76 (1.12–2.77)

0.015

0.037

1.75 (0.99–3.08)

0.052

0.156

1.28 (0.78–2.08)

0.326

0.671

 

Parietal TBR

1.75 (1.15–2.66)

0.009

0.032

1.48 (0.91–2.42)

0.117

0.246

1.22 (0.79–1.90)

0.363

0.671

 

Occipital TBR

1.66 (1.10–2.48)

0.015

0.037

1.74 (1.05–2.87)

0.031

0.109

1.38 (0.88–2.14)

0.158

0.671

 

Frontal theta

2.69 (1.02–7.06)

0.045

0.068

4.40 (1.28–15.14)

0.019

0.109

1.23 (0.44–3.48)

0.691

0.691

 

Temporal theta

3.57 (1.44–8.85)

0.006

0.032

3.81 (1.24–11.73)

0.020

0.199

1.29 (0.50–3.35)

0.604

0.691

 

Central theta

3.80 (1.43–10.09)

0.008

0.032

5.12 (1.47–17.87)

0.010

0.109

1.46 (0.53–4.06)

0.465

0.671

 

Parietal theta

3.55 (1.43–8.82)

0.006

0.032

3.48 (1.17–10.29)

0.024

0.109

1.34 (0.53–3.38)

0.537

0.671

 

Occipital theta

2.55 (1.13–5.73)

0.024

0.046

3.12 (1.14–8.54)

0.026

0.109

1.70 (0.71–4.09)

0.235

0.671

 

Frontal beta1

0.41 (0.20–0.86)

0.018

0.038

0.76 (0.34–1.71)

0.511

0.623

0.71 (0.33–1.53)

0.385

0.671

 

Temporal beta1

0.39 (0.19–0.79)

0.009

0.032

0.64 (0.29–1.42)

0.273

0.410

0.57 (0.27–1.20)

0.139

0.671

 

Central beta1

0.47 (0.22–0.997)

0.049

0.069

0.71 (0.29–1.74)

0.456

0.599

0.63 (0.27–1.45)

0.274

0.671

 

Parietal beta1

0.47 (0.24–0.92)

0.029

0.048

0.78 (0.36–1.70)

0.534

0.623

0.73 (0.35–1.50)

0.387

0.671

 

Occipital beta1

0.47 (0.24–0.93)

0.030

0.048

0.54 (0.24–1.22)

0.140

0.267

0.54 (0.26–1.14)

0.104

0.671

 

Frontal beta2

0.68 (0.40–1.15)

0.151

0.175

0.79 (0.43–1.46)

0.790

0.790

0.88 (0.49–1.58)

0.667

0.691

 

Temporal beta2

0.62 (0.37–1.05)

0.077

0.101

0.90 (0.48–1.67)

0.740

0.777

0.89 (0.50–1.57)

0.677

0.691

 

Central beta2

0.69 (0.41–1.17)

0.167

0.175

0.75 (0.40–1.41)

0.375

0.525

0.82 (0.46–1.47)

0.511

0.671

 

Parietal beta2

0.71 (0.44–1.15)

0.159

0.175

0.87 (0.49–1.53)

0.623

0.689

0.82 (0.48–1.39)

0.452

0.671

 

Occipital beta2

0.68 (0.43–1.09)

0.109

0.135

0.69 (0.39–1.23)

0.209

0.360

0.85 (0.51–1.43)

0.543

0.671

DAT biomarker

VST

0.39 (0.21–0.72)

0.003

0.005

0.42 (0.21–0.81)

0.010

0.013

0.66 (0.36–1.22)

0.189

0.252

 

Putamen

0.52 (0.33–0.81)

0.004

0.005

0.42 (0.24–0.72)

0.002

0.008

0.52 (0.32–0.86)

0.010

0.040

 

Caudate

0.46 (0.27–0.78)

0.004

0.005

0.60 (0.32–1.11)

0.105

0.105

0.80 (0.46–1.40)

0.437

0.437

 

Caudate/PP

0.25 (0.03–2.30)

0.221

0.221

52.97 (3.36-834.72)

0.005

0.010

16.61 (1.49-185.45)

0.022

0.044

  1. Data were obtained from univariable logistic regression analyses of clinical symptoms using EEG or DAT biomarkers as a predictor, after controlling for age, sex, and education. Significant correlations (Q value < 0.05) are expressed in bold.
  2. DAT dopamine transporter, EEG electroencephalography, PDR Posterior dominant rhythm, P P value, PP posterior putamen, Q FDR-corrected P value, RBD rapid eye movement sleep behavior disorder, TBR theta-to-beta ratio, VST Ventral striatum.
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