Fig. 2 | Scientific Reports

Fig. 2

From: Anti PD-L1 immunotherapy alters macrophage phenotypes via EGR1 and HSP90AB1 supported by integrated methodologies

Fig. 2

Analysis of circulating macrophage enrichment and transcription factor activity in the chemotherapy (CHEMO) group and the group receiving chemotherapy in combination with a PD-L1 inhibitor (ANTI-PD-L1 + CHEMO) therapy. (A) GO enrichment analysis of differentially expressed genes in macrophages between the CHEMO group and ANTI-PD-L1 + CHEMO group. (B) KEGG enrichment analysis of differentially expressed genes in macrophages between the CHEMO group and ANTI-PD-L1 + CHEMO group. (C) GSVA enrichment analysis of differentially expressed genes in macrophages between the CHEMO group and ANTI-PD-L1 + CHEMO group. (D) Heatmap depicting transcription factor enrichment in macrophage subsets in both groups.

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