Fig. 1 | Scientific Reports

Fig. 1

From: Erdafitinib suppresses pathological retinal angiogenesis via dual targeting of FGFR and VEGFR2 signaling

Fig. 1

Erdafitinib suppresses developmental angiogenesis in zebrafish (A) Chemical structure of erdafitinib (molecular weight: 447.35 g/mol). (B) Relative survival rate of zebrafish embryos(n = 30 embryos/group) demonstrates that Erdafitinib (2–4µM) treatment does not exhibit cytotoxicity in zebrafish embryos (p < 0.05) (C) Representative, lateral-view pictures of Tg(fli1: EGFP) control and Erdafitinib-treated embryos at 30 hpf. Enlargement of the tail of embryos shown above. Red squares point to the Intersegmental Vessels(ISVs)considered for the measurement. (D) The graph represent the mean values obtained for ISVs length, respectively, both in control and treated embryos. Three replicates were performed, with 30 embryos per group. p < 0.001; Scale bar = 100 μm.

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