Fig. 4 | Scientific Reports

Fig. 4

From: Erdafitinib suppresses pathological retinal angiogenesis via dual targeting of FGFR and VEGFR2 signaling

Fig. 4

Molecular Docking Diagram. Molecular model of Erdafitinib binding with VEGFR2, presented in both 3D and 2D diagrams. (A) 3D binding pose showing hydrogen bonds (yellow dashes) with VEGFR2 kinase domain residues (PDB: 3VHE). (B) 2D interaction map. Key residues: K868 (salt bridge), D1046 (H-bond), F1045 (π-π stacking). (C) Binding affinity comparison: VEGFR2 (−7.8 kcal/mol) vs. FGFR1 (−10.2 kcal/mol).

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