Table 11 Physico–chemical parameters of BPhIM and APhIM.

From: Structural, nonlinear optical, and molecular docking studies of schiff base compounds as multi-target inhibitors of AChE, BChE, and carbonic anhydrases

Descriptor

TPSA (Ų)a

MlogPb

NHDc

NHAd

NRBe

MW (g/mol)f

Lipinski’s violation

BPhIM

41.82

2.91

1

3

3

306.15

0

APhIM

67.84

1.67

2

3

3

242.27

0

Preferred

\(\:<500\)

\(\:<5\)

\(\:\le\:5\)

\(\:\le\:10\)

\(\:\le\:10\)

\(\:<500\)

\(\:0\)

  1. a Topological polar surface area.
  2. b calculated lipophilicity.
  3. c Number of hydrogen bond donors.
  4. d Number of hydrogen bond acceptors.
  5. e Number of rotatable bonds.
  6. f Molecular weight.
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