Fig. 6 | Scientific Reports

Fig. 6

From: Novel anti-LAG-3 antibody LBL-007 with anti-PD-1 blockade enhances antitumor immunity by promoting T cell-induced apoptosis

Fig. 6

LBL-007 and anti-PD-1 antibodies inhibit mouse colorectal cancer cell growth in vivo. C57BL/6-hLAG-3 mice (n = 56) were randomly divided into 7 groups (n = 8 mice/group) when the MC38 colon adenocarcinoma tumor volume reached approximately 80 mm3. Then, mice were treated with IgG (10 mg/kg), LBL-007 (0.3 mg/kg-10.0 mg/kg), BE0146 (mouse anti-PD-1 antibody, 10 mg/kg), or a combination of LBL-007 (10 mg/kg) and BE0146 (10 mg/kg) twice a week. The tumor volume was calculated at the end of the experiment. Results are expressed as the mean tumor volume ± SD. *P < 0.05, **P < 0.01.

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