Fig. 2
TCRβ/γ evenness as a predictor of clinical response and patient survival. (A) Responders (R) have statistically significant lower tumor-infiltrating TCRβ evenness than non-responders (NR) (p = 0.044). P was obtained using Student’s t test. (B) Tumor-infiltrating TCRβ evenness predicts response with an AUC of 0.86. A lower tumor-infiltrating TCRβ evenness than 0.795 have a 60% sensitivity and 100% specificity predicting response. (C) Patients with low tumor-infiltrating TCRβ evenness have statistically significant longer PFS than patients with high tumor-infiltrating TCRβ evenness (p = 0.013). P was obtained using Log-Rank test. (D) R have a non-statistically significant lower circulating TCRβ evenness than NR (p = 0.139). P was obtained using Student’s t test. (E) R have a non-statistically significant lower tumor-infiltrating TCRγ evenness than NR (p = 0.149). P-value was obtained using Mann-Whitney test. (F) R have a non-statistically significant lower circulating TCRγ evenness than NR (p = 0.114). P was obtained using Mann-Whitney test. AUC: Area Under the Curve, N: number of patients, NE: non-evaluable, PD: progressive disease, PFS: progression-free survival, PR: partial response, SD: stable disease, *: statistical significance.
