Fig. 4 | Scientific Reports

Fig. 4

From: Tissue and peripheral T cell receptor repertoire predicts immunotherapy response and progression-free survival in NSCLC patients

Fig. 4

Tumor-infiltrating and circulating TCRβ predictive signatures for clinical response. (A) A predictive signature including tumor-infiltrating TCRβ variables (evenness, TRBV6.5 frequency, TRBV11.3 frequency and TRBJ2.1 frequency) predicts response with an AUC of 0.83. A positive result has an 100% sensitivity and 71.4% specificity predicting response. (B) A predictive signature including circulating TCRβ variables (TRBV5.3 frequency, TRBV27 frequency, TRBV28 frequency, TRBJ2.1 frequency and TRBJ2.6 frequency) predicts response with an AUC of 0.92. A positive result has an 75% sensitivity and 100% specificity predicting response. AUC: Area Under the Curve.

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