Table 1 Clinicopathologic characteristics of patients.
Clinicopathologic characteristics | Responders | Non-responders | Cohort | |||
|---|---|---|---|---|---|---|
Tissue (N = 5) | Blood (N = 4) | Tissue (N = 7) | Blood (N = 6) | Tissue (N = 12) | Blood (N = 10) | |
Age (years) | ||||||
Median (range) | 74 (71–81) | 74.5 (71–81) | 60 (43–71) | 56.5 (43–71) | 70.5 (43–81) | 67.5 (43–81) |
Sex | ||||||
Male | 4 | 3 | 5 | 5 | 9 | 8 |
Female | 1 | 1 | 2 | 1 | 3 | 2 |
Smoking status | ||||||
Smoker | 2 | 1 | 4 | 3 | 6 | 4 |
Former smoker | 3 | 3 | 2 | 2 | 5 | 5 |
Never smoker | 0 | 0 | 1 | 1 | 1 | 1 |
Histology | ||||||
Squamous | 2 | 1 | 1 | 1 | 3 | 2 |
Adenocarcinoma | 3 | 3 | 6 | 5 | 9 | 8 |
Stage | ||||||
IIIA | 0 | 0 | 1 | 0 | 1 | 0 |
IIIC | 0 | 0 | 1 | 1 | 1 | 1 |
IVA | 4 | 3 | 0 | 0 | 4 | 3 |
IVB | 1 | 1 | 5 | 5 | 6 | 6 |
PD1/PD-L1 | ||||||
Positive | 4 | 3 | 6 | 6 | 10 | 9 |
Negative | 1 | 1 | 1 | 0 | 2 | 1 |
Response type | ||||||
CR | 0 | 0 | 0 | 0 | 0 | 0 |
PR | 3 | 2 | 0 | 0 | 3 | 2 |
SD | 2 | 2 | 0 | 0 | 2 | 2 |
PD | 0 | 0 | 4 | 3 | 4 | 3 |
NE | 0 | 0 | 3 | 3 | 3 | 3 |
PFS (days) | ||||||
Median (range) | 328 (116–952) | 245 (116–952) | 72 (3–148) | 71 (4–148) | 100 (4–952) | 100 (4–952) |
OS (days) | ||||||
Median (range) | 405 (126–952) | 512 (126–952) | 113 (4–364) | 85.5 (4–364) | 225 (4–952) | 145.5 (4–952) |
