Table 3 KEGG pathway enrichment analysis of luteolin against dry AMD.

From: Mechanistic analysis of luteolin in mitigating dry age-related macular degeneration through network pharmacology and experimental validation

Pathway ID

KEGG_B_class

Pathway

P

Gene

hsa05417

Cardiovascular disease

Lipid and atherosclerosis

1.14E-39

GSK3B, CD40, CXCL8, TNF, ICAM1, CASP9, CASP7, TBK1, CASP8, CASP3, TNFSF10, CASP1, AKT1, HSP90AA1, MMP1, MMP3, PRKCA, FOS, MMP9, ERN1, IRF3, IL1B, DDIT3, PPARG, ATF6, TP53, SRC, AGER, MAPK8, CCL2, MAPK1, NLRP3, MAPK3, JUN, XBP1, VCAM1, HSPA5, IFNB1, NOS3, STAT3, SOD2, SELE, EIF2S1, NFKB1, MAPK10, IL6, CD40LG, CYP1A1, BCL2, BAX, FAS, NFE2L2, BCL2L1

hsa05200

Cancer

Pathways in cancer

1.12E-34

ALK, GSK3B, CDKN1A, CDKN1B, CXCL8, PTEN, SLC2A1, KEAP1, FGF2, IGF1R, CASP9, CASP7, CASP8, CCND1, CDH1, CASP3, AKT1, JAK1, HSP90AA1, MMP1, MMP2, IL13, PRKCA, FOS, F2, MMP9, CCNA2, AR, IFNG, PPARG, MET, TP53, BIRC2, PDGFB, CXCR4, XIAP, PTGS2, HIF1A, EGFR, MAPK8, TERT, HMOX1, MAPK1, MAPK3, NQO1, JUN, TGFB1, NOS2, EGF, STAT1, STAT3, ESR1, MTOR, NFKB1, VEGFA, MAPK10, IL4, IL6, IL5, CXCL12, CDK6, CDK2, GSTA1, BCL2, MDM2, BAX, CTNNB1, FAS, NFE2L2, BCL2L1

hsa04933

Endocrine and metabolic disease

AGE-RAGE signaling pathway in diabetic complications

7.59E-26

CDKN1B, CXCL8, SERPINE1, TNF, AGER, ICAM1, MAPK8, CCND1, CASP3, CCL2, AKT1, MAPK1, MAPK3, EGR1, JUN, TGFB1, VCAM1, NOS3, STAT1, MMP2, STAT3, PRKCA, SELE, NFKB1, VEGFA, MAPK10, IL6, IL1B, BCL2, BAX, NOX4

hsa04657

Immune system

IL-17 signaling pathway

2.17E-25

GSK3B, CSF2, CXCL8, TNFAIP3, PTGS2, TNF, MAPK8, CASP8, TBK1, CASP3, CCL2, MAPK1, MAPK3, JUN, HSP90AA1, MMP1, IL13, MMP3, FOS, MMP9, NFKB1, MAPK10, IL4, CXCL10, IL6, MMP13, IL5, IFNG, IL1B, IL17A

hsa05167

Infectious disease: viral

Kaposi sarcoma-associated herpesvirus infection

4.40E-24

BECN1, GSK3B, CDKN1A, CSF2, CXCL8, SRC, PDGFB, PTGS2, FGF2, HIF1A, ICAM1, CASP9, MAP1LC3B, MAPK8, CASP8, TBK1, CCND1, CASP3, AKT1, MAPK1, JAK1, MAPK3, JUN, IFNB1, STAT1, STAT3, FOS, MTOR, NFKB1, VEGFA, MAPK10, IL6, CDK6, IRF3, BAX, CTNNB1, FAS, TP53

hsa05162

Infectious disease: viral

Measles

1.52E-22

GSK3B, CDKN1B, TNFAIP3, CASP9, MAPK8, CASP8, TBK1, CCND1, CASP3, AKT1, JAK1, JUN, CSNK2A1, IFNB1, STAT1, STAT3, FOS, EIF2S1, NFKB1, MAPK10, IL6, CDK6, IRF3, IL1B, CSNK2B, CDK2, BCL2, BAX, FAS, TP53, BCL2L1, TP73

hsa05418

Cardiovascular disease

Fluid shear stress and atherosclerosis

3.31E-21

PRKAA1, SRC, PDGFB, KEAP1, TNF, ICAM1, CDH5, MAPK8, KDR, CCL2, AKT1, HMOX1, NQO1, JUN, HSP90AA1, VCAM1, NOS3, MMP2, FOS, SELE, MMP9, NFKB1, VEGFA, MAPK10, IFNG, IL1B, GSTA1, BCL2, CTNNB1, TP53, NFE2L2

hsa04668

Signal transduction

TNF signaling pathway

6.08E-20

CSF2, XIAP, TNFAIP3, PTGS2, TNF, ICAM1, CASP7, MAPK8, CASP8, CASP3, CCL2, AKT1, MAPK1, MAPK3, JUN, VCAM1, IFNB1, MMP3, FOS, SELE, MMP9, NFKB1, MAPK10, CXCL10, IL6, IL1B, FAS, BIRC2

hsa01521

Drug resistance: antineoplastic

EGFR tyrosine kinase inhibitor resistance

1.19E-19

GSK3B, SRC, EGF, STAT3, PTEN, PDGFB, PRKCA, FOXO3, FGF2, EGFR, MTOR, IGF1R, VEGFA, IL6, AXL, KDR, BCL2, BAX, AKT1, MAPK1, MET, JAK1, BCL2L1, MAPK3

hsa05161

Infectious disease: viral

Hepatitis B

2.66E-19

CDKN1A, CXCL8, SRC, TNF, CASP9, MAPK8, CASP8, TBK1, CASP3, AKT1, MAPK1, JAK1, MAPK3, JUN, TGFB1, IFNB1, STAT1, STAT3, PRKCA, FOS, MMP9, NFKB1, MAPK10, CCNA2, IL6, IRF3, CDK2, BCL2, BAX, FAS, TP53

hsa04210

Cell growth and death

Apoptosis

2.43E-18

XIAP, TNF, CASP9, CASP7, MAPK8, CASP8, CASP3, TNFSF10, AKT1, MAPK1, CAPN1, CTSD, MCL1, MAPK3, JUN, PARP1, FOS, EIF2S1, NFKB1, ERN1, MAPK10, DDIT3, BCL2, BAX, FAS, TP53, BIRC2, BCL2L1

hsa05163

Infectious disease: viral

Human cytomegalovirus infection

5.93E-18

GSK3B, CDKN1A, CXCL8, SRC, CXCR4, PTGS2, TNF, EGFR, CASP9, CASP8, TBK1, CCND1, CASP3, CCL2, AKT1, MAPK1, JAK1, MAPK3, IFNB1, STAT3, PRKCA, MTOR, NFKB1, VEGFA, IL6, CXCL12, CDK6, IRF3, IL1B, MDM2, BAX, CTNNB1, FAS, TP53

hsa05164

Infectious disease: viral

Influenza A

1.34E-17

CXCL8, PLG, TNF, ICAM1, CASP9, CASP8, TBK1, CASP3, CASP1, TNFSF10, CCL2, AKT1, MAPK1, NLRP3, JAK1, MAPK3, IL33, IFNB1, STAT1, PRKCA, EIF2S1, NFKB1, CXCL10, IL6, CDK6, IFNG, IRF3, IL1B, BAX, FAS

hsa05160

Infectious disease: viral

Hepatitis C

1.54E-17

GSK3B, CDKN1A, TNF, EGFR, CASP9, CASP8, TBK1, CCND1, CASP3, AKT1, MAPK1, JAK1, MAPK3, IFNB1, EGF, STAT1, STAT3, EIF2S1, NFKB1, CXCL10, OCLN, CDK6, IFNG, IRF3, CDK2, BAX, CTNNB1, FAS, TP53

hsa05215

Cancer

Prostate cancer

1.76E-17

GSK3B, CDKN1A, HSP90AA1, CDKN1B, EGF, MMP3, PTEN, PDGFB, MMP9, EGFR, MTOR, NFKB1, IGF1R, CASP9, AR, CCND1, CDK2, MDM2, BCL2, AKT1, MAPK1, CTNNB1, TP53, MAPK3

hsa05169

Infectious disease: viral

Epstein-Barr virus infection

1.55E-16

CDKN1A, CD40, CDKN1B, TNFAIP3, TNF, ICAM1, CASP9, MAPK8, CASP8, TBK1, CCND1, CASP3, AKT1, JAK1, JUN, IFNB1, STAT1, STAT3, NFKB1, MAPK10, CCNA2, CXCL10, IL6, CDK6, IRF3, CDK2, BCL2, MDM2, BAX, FAS, TP53

hsa04066

Signal transduction

HIF-1 signaling pathway

2.20E-16

CDKN1A, CDKN1B, PFKFB3, NOS2, NOS3, EGF, INSR, STAT3, SERPINE1, SLC2A1, PRKCA, HIF1A, EGFR, MTOR, NFKB1, IGF1R, VEGFA, IL6, IFNG, BCL2, AKT1, HMOX1, MAPK1, MAPK3

hsa05212

Cancer

Pancreatic cancer

2.87E-16

CDKN1A, TGFB1, STAT1, EGF, STAT3, EGFR, MTOR, NFKB1, VEGFA, MAPK10, CASP9, MAPK8, CDK6, CCND1, BAX, AKT1, MAPK1, TP53, JAK1, BCL2L1, MAPK3

hsa05145

Infectious disease: parasitic

Toxoplasmosis

3.37E-16

IL10, CD40, TGFB1, NOS2, STAT1, STAT3, XIAP, TNF, NFKB1, MAPK10, CASP9, MAPK8, CASP8, CD40LG, IFNG, CASP3, ALOX5, BCL2, AKT1, MAPK1, BIRC2, JAK1, BCL2L1, MAPK3

hsa05208

Cancer

Chemical carcinogenesis—reactive oxygen species

5.12E-16

SRC, PTEN, KEAP1, AHR, FOXO3, HIF1A, EGFR, MAPK8, CYP1B1, AKT1, HMOX1, MAPK1, MAPK3, NQO1, JUN, EGF, AKR1A1, PTPN11, FOS, SOD2, NFKB1, SOD1, VEGFA, MAPK10, CYP1A2, CAT, GSTA1, CYP1A1, NOX4, CYP2E1, MET, NFE2L2

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