Fig. 4 | Scientific Reports

Fig. 4

From: USP15-dependent modulation of TGF-β/Smad2/3 signaling: implications for chondrocyte matrix degradation and autophagy in osteoarthritis

Fig. 4

Effects of knockdown and overexpression of USP15 in human OA chondrocytes on the ability of chondrocytes to synthesize Col-II and Aggrecan. (A) Human OA chondrocytes knocking down USP15 expression, WB detection of Col-II and Aggrecan expression; (B) human OA chondrocytes overexpressing USP15, WB detection of Col-II and Aggrecan expression. *p < 0.05, Data are representative of three independent experiments using primary chondrocytes from 25 OA patients (n = 25 biological replicates). Values are mean ± SD.

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