Table 2 Univariate COX regression analysis of overall survival in patients with cT1b renal cancer.

From: Machine learning prediction of overall survival in patients with cT1b renal cell carcinoma after surgical resection using the SEER database

Characteristics

Number (%)

Hazard ratio (HR)

Lower_95

Upper_95

P-value

Age*

60.73 (12.46)

1.053

1.05

1.055

 < 0.001

Histological_subtypes*

 ccRCC

15,659 (69.8)

    

 pRCC

2396 (10.7)

0.991

0.912

1.078

0.836

 chRCC

926 (4.1)

0.504

0.429

0.593

 < 0.001

 nosRCC

3445 (15.4)

1.218

1.145

1.297

 < 0.001

Household_income*

 < $54,999

4331 (19.3)

    

 $55,000–$74,999

10,131 (45.2)

0.872

0.817

0.93

 < 0.001

 > $75,000

7964 (35.5)

0.816

0.762

0.874

 < 0.001

Laterality

 Left side

11,106 (49.5)

    

 Right side

11,320 (50.5)

0.98

0.933

1.03

0.423

pM*

 pM0

21,317 (95.1)

    

 pM1

1109 (4.9)

7.163

6.660

7.704

 < 0.001

Marital*

 Married

14,367 (64.1)

    

 Single/unmarried

3565 (15.9)

1.025

0.953

1.103

0.508

 Separation/divorce

2554 (11.4)

1.189

1.1

1.286

 < 0.001

 Others

1940 (8.7)

1.965

1.824

2.117

 < 0.001

pN*

 pN0

21,830 (97.3)

    

 pN1

596 (2.7)

6.783

6.175

7.451

 < 0.001

Grade*

 Ⅰ

2109 (9.4)

    

 Ⅱ

11,595 (51.7)

1.045

0.951

1.149

0.358

 Ⅲ

7139 (31.8)

1.585

1.44

1.745

 < 0.001

 Ⅳ

1583 (7.1)

3.513

3.141

3.928

 < 0.001

Race

 Black

2203 (9.8)

    

 White

18,675 (83.3)

0.959

0.884

1.042

0.323

 Other

1548 (6.9)

0.847

0.746

0.961

0.01

Regional_nodes_examined*

 No

19,900 (88.7)

    

 Yes

2526 (11.3)

1.602

1.496

1.715

 < 0.001

Regional_nodes_positive*

 No

22,015 (98.2)

    

 Yes

411 (1.8)

6.33

5.652

7.088

 < 0.001

Sex*

 Male

14,214 (63.4)

    

 Female

8212 (36.6)

0.856

0.813

0.902

 < 0.001

pT*

 pT1b

17,268 (77.0)

    

 pT3a

3480 (15.5)

2.006

1.881

2.14

 < 0.001

 pT3b

1549 (6.9)

2.611

2.426

2.81

 < 0.001

 pT3c

50 (0.2)

3.556

2.468

5.125

 < 0.001

 pT4

79 (0.4)

8.346

6.465

10.775

 < 0.001

 Tumor_size*

54.40 (8.57)

1.021

1.018

1.024

 < 0.001

Types_of_Surgery*

 PN

4780 (21.3)

    

 RN

17,646 (78.7)

1.846

1.707

1.995

 < 0.001

Urban_rural_residence

 Counties in metropolitan areas of < 250 thousand people

1937 (8.6)

    

 Counties in metropolitan areas of 250,000 ~ 1 million people

4912 (21.9)

0.925

0.838

1.02

0.118

 Counties in metropolitan areas ≥ 1 million pop

12,396 (55.3)

0.907

0.83

0.991

0.032

 Nonmetropolitan counties adjacent to a metropolitan area

1793 (8.0)

1.019

0.906

1.146

0.756

 Nonmetropolitan counties not adjacent to a metropolitan area

1388 (6.2)

1.129

0.996

1.279

0.057

  1. PN, Partial nephrectomy; RN, Radical nephrectomy; ccRCC, Clear cell renal cell carcinoma; pRCC, Papillary renal cell carcinoma; chRCC, Chromophobe renal cell carcinoma; nosRCC, Not otherwise specified renal cell carcinoma.
  2. *Characterization variables ultimately included.
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