Fig. 3

First cancer classified according to core cancers in LFS and distribution of familial phenotypical classification in the Swedish cohort. (a) First cancer in each patient classified according to the cancers: adrenocortical carcinoma (ACC), breast cancer, central nervous system (CNS) tumor, sarcoma and prostate cancer, all other cancers classified as “other”. Categorized by only p.R181H carriers (p.R181H), all carriers of other variants (non-p.R181H), missense variants except p.R181H (missense) and patients classified as hereditary breast cancer except p.R181H carriers (HBC). Corresponding proportions written as percentages in each bar. (b) Proportion of families classified as the phenotypical classes classic LFS, Chompret and HBC, all other families classified as “other”. Categorized by only p.R181H carriers (p.R181H), all carriers of other variants (non-p.R181H) and missense variants except p.R181H (missense). Corresponding proportions written as percentages in each bar.