Fig. 4 | Scientific Reports

Fig. 4

From: Unveiling the therapeutic potential of silibinin in head and neck squamous cell carcinoma via network pharmacology

Fig. 4

Molecular docking results obtained using AutoDock 1.5.7 software (https://github.com/ScrippsResearch/AutoDock). (a) Molecular docking results of MMP13 and silibinin. (b) Molecular docking results of SLCO1B1 and silibinin. (c) Molecular docking results of SLCO1B3 and silibinin. (d) RT-qPCR experiments and Western-blotting analysis of SLCO1B3 expression in the HNSCC cell line and human oral mucosal precancerous cells DOK. (*P < 0.05). (e) The CCK-8 assay suggests that silibinin inhibits the viability of CAL27 and HSC-3 cells in a time- and concentration-dependent manner. (f) Colony Formation Assay. (*P < 0.05) (g) Transwell Invasion Assay, Proportion of migrated HNSCC cells using the Transwell Invasion Assay. (*P < 0.05)

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