Table 6 Univariate and multivariable analyses for overall survival.

From: Impact of preoperative comorbidities on postoperative complication rates and survival outcome in patients with head and neck cancer undergoing surgical treatment

Variables

Univariate analysis

Multivariate analysis*

HR (95% CI)

P value

HR (95% CI)

P value

Age (≥70)

1.87(1.17-2.99)

0.009

1.39(0.75-2.58)

0.291

Comorbidity

1.56(0.91-2.70)

0.107

/

/

ACE-27 (2-3)

0.79(0.41-1.54)

0.487

/

/

CCI (≥4)

2.27(1.43-3.60)

<0.001

1.68(1.02-2.78)

0.043

ASA Ⅲ-Ⅳ

2.98(1.84-4.85)

<0.001

2.40(1.43-4.02)

<0.001*

Tumor subsite (oral cavity)

1.42(0.76-2.63)

0.27

/

/

Diagnosis (OSCC)

1.47(0.85-2.52)

0.168

/

/

Preoperative adjuvant therapy

2.52(1.40-4.51)

0.002

2.13(1.17-3.88)

0.013*

pT 3-4

1.57(0.98-2.53)

0.06

/

/

pN 1-3

2.17(1.36-3.46)

0.001

2.12(1.32-3.40)

0.002*

Operative time (>3h)

1.94(1.02-3.68)

0.044

1.24(0.60-2.55)

0.604

Flap reconstruction

0.67(0.42-1.06)

0.088

/

/

Surgical complication

2.05(1.24-3.38)

0.005

0.58(0.12-2.71)

0.485

Medical complication

1.21(0.49-3.02)

0.68

/

/

CDC grades Ⅲ-Ⅴ

2.55(1.27-5.14)

0.009

2.19(0.95-5.08)

0.067

  1. *Cox proportional hazards model.HR, hazard ratio; ACE, Adult comorbidity evaluation; CCI, Charlson comorbidity index; ASA, American society of anesthesiologists; OSCC, Oral squamous cell carcinoma; CDC, Clavien-dindo classification
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