Table 1 Demographic and laboratory characteristics of the study participants.

From: Glial and neuronal cell-free DNA in plasma of sporadic bvFTD and late onset primary psychiatric disease patients

 

Sporadic bvFTD (mean ± sd)

Late onset PPD (mean ± sd)

GLM coefficients

N

179

102

–

Age (years, disease onset)

59.8 ± 9.4

53.5 ± 8.6

0.019**

Age (years, blood draw)

63.7 ± 9.2

58.2 ± 8.0

− 0.004

Sex (M)

59.7%

71.0%

− 0.097

Plasma volume (mL)

0.6 ± 0.2

0.6 ± 0.1

− 0.0001

cfDNA (ng/µL plasma)

56.0 ± 245.0

44.1 ± 127.0

− 0.001

cfDNA (ng)

36.3 ± 181.0

27.3 ± 77.6

0.001

Reads (M)

4.63 ± 2.76

4.16 ± 2.43

− 0.000

Bisulfite Conversion (%)

99.5 ± 0.37

99.5 ± 0.28

− 0.105

Glia-cfDNA (FPM)

50,368 ± 67,484

52,917 ± 68,497

0.00000

Neuron-cfDNA (FPM)

33,099 ± 66,432

39,435 ± 66,645

0.00000

Neuron: Glia ratio (NGR)

0.36 ± 0.36

0.56 ± 0.36

− 0.197***

Constant

–

–

10.161

Observations

–

–

254

Log likelihood

–

–

− 152.650

Akaike Inf. Crit.

–

–

329.300

  1. **p = 0.01; ***p = 0.0002.
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