Table 1 The 50% growth inhibition (GI50), total growth inhibition (TGI) and 50% lethal (LC50) concentrations of ZOT5-1-Me, ZOT5-1-Et, carmustine (BCNU), lomustine (CCNU), and temozolomide (TMZ) towards the glioblastoma and astrocytoma cell lines. Results were obtained in the NCI-60 five-dose screen.
Indices | SF-268 | SF-295 | SF-539 | SNB-19 | SNB-75 | U251 |
|---|---|---|---|---|---|---|
ZOT5-1-Me | ||||||
GI50 | 24.2 µM | 16.5 µM | 2.55 µM | 24.8 µM | 4.93 µM | 17.6 µM |
TGI | 64.2 µM | 31.8 µM | 7.21 µM | 77.0 µM | 55.3 µM | 38.0 µM |
LC50 | > 100 µM | 61.0 µM | 32.7 µM | > 100 µM | > 100 µM | 82.1 µM |
ZOT5-1-Et | ||||||
GI50 | 17.9 µM | 15.6 µM | 2.02 µM | 26.2 µM | 1.95 µM | 20.7 µM |
LC50 | 54.4 µM | 33.2 µM | 4.75 µM | > 100 µM | 36.7 µM | 60.2 µM |
TGI | > 100 µM | 70.9 µM | > 100 µM | > 100 µM | > 100 µM | > 100 µM |
BCNU | ||||||
GI50 | 13.7 µM | 4.6 µM | 15.4 µM | 17.5 µM | 27.0 µM | 12.0 µM |
TGI | 212.8 µM | 422.7 µM | 170.6 µM | 218.3 µM | 140.9 µM | 240.4 µM |
LC50 | 350.8 µM | 473.2 µM | 239.9 µM | 305.5 | 342.0 µM | 346.7 µM |
CCNU | ||||||
GI50 | 24.6 µM | 32.0 µM | 23.9 µM | 52.5 µM | 37.2 µM | 31.6 µM |
TGI | 124.2 µM | 117.5 µM | 85.1 µM | 121.9 µM | 113.8 µM | 104.2 µM |
LC50 | 373.3 µM | 266.1 µM | 219.8 µM | 257.0 µM | 267.9 µM | 258.8 µM |
TMZ | ||||||
GI50 | > 100 µM | > 100 µM | > 100 µM | > 100 µM | 70.8 µM | > 100 µM |
TGI | > 100 µM | > 100 µM | > 100 µM | > 100 µM | > 100 µM | > 100 µM |
LC50 | > 100 µM | > 100 µM | > 100 µM | > 100 µM | > 100 µM | > 100 µM |
