Table 3 Comparison of baseline demographic data and system inflammatory bioparameters in different stages of DME based on SD-OCT.

From: Shifting of the local inflammatory characteristics of diabetic macular edema manifested in SD-OCT after anti-VEGF treatment and associations with system inflammatory bioparameters

Characteristics

Early DME (n = 37)

Advanced DME (n = 35)

Severe DME (n = 36)

Atrophic DME (n = 18)

P-value

Gender, n (%)

0.616

 Male

20(54.05)

20(57.14)

19(52.78)

8(44.44)

 

 Female

17(45.95)

15(42.86)

17(47.22)

10(55.56)

 

Age, years, median (IQR)

58.90(50.48, 66)

60.23(55.44, 62.97)

61.64(56.80, 67.01)

62.53(53.36, 71.76)

0.349

Duration of DM, years, median (IQR)

10.14(8.00, 12.11)

11.21(8.35, 12.67)

10.32(8.03, 12.63)

16.7(11.49, 19.82)

0.336

Diabetic retinopathy grading, n (%)

1

 Mild or moderate NPDR

13(35.14)

14(40)

16(44.44)

7(38.89)

 

 Severe NPDR

16(43.24)

15(42.86)

15(41.67)

9(50)

 

 PDR

8(21.62)

6(17.14)

5(13.89)

2(11.11)

 

System inflammatory bioparameters, and median (IQR)

 HbA1c, %

7.46(4.25, 10.52)

6.70(4.98, 5.42)

7.05(4.34, 10.80)

7.55(5.37, 9.96)

0.848

 CRP, mg/L

1.67(0.63, 2.43)

0.82(0.63, 1.4)

1.66(1.30, 2.76)b

3.86(2.24, 5.71)a, b,c

< 0.001

 NLR

2.4(1.23, 3.95)

1.57(1.30, 3.28)a

2.31(1.36, 3.50)

4.91(2.33, 5.79)a, b,c

< 0.001

 MLR

0.35(0.23, 0.46)

0.29(0.18, 0.37)

0.32(0.18, 0.38)

0.51(0.28, 0.68)a, b,c

< 0.001

 PLR

131.91(84.46, 237.09)

101.28(69.19, 191.43)

117.61(53.49, 188.41)

178.36(87.15, 329.90)b, c

< 0.001

 SII

758(466.13, 895.87)

497.24(407.05, 672.38)a

629.02(336.10, 898.41)

1620.61(1008.27, 1884.40)a, b,c

< 0.001

  1. DM diabetes mellitus, NPDR nonproliferative diabetic retinopathy, PDR proliferative diabetic retinopathy, HbA1c glycosylated hemoglobin, CRP C-reactive protein, NLR neutrophil-to-lymphocyte ratio, MLR monocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammation index.
  2. ap < 0.008 compared with early DME.
  3. bp < 0.008 compared with advanced DME.
  4. cp < 0.008 compared with severe DME (Bonferroni correction).
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