Fig. 7
From: PKA prevents the resection of DNA double-strand breaks and favours nonhomologous end-joining
The different roles of PKA in NHEJ. At the earliest step of DSB repair, PKA promotes and/or stabilizes the loading of 53BP1 on DSBs, impairing resection and fostering NHEJ. Resection repression leads to decreased HR efficiency. However, PKA can also act at later steps of NHEJ through the nuclear translocation of DNA-PK and the expression of NHEJ factors, including ligase IV and its cofactors (XRCC4 and XLF/Cernunos).
