Table 2 Relationships between regional intra-WMH T1w, T2w, FDG or AV45 signal in each brain lobe and cognition (MMSE).

From: Heterogeneity of white matter hyperintensities in Alzheimer’s disease captured by multimodal neuroimaging

 

T1w

T2w

 

Beta (β)

Standard errors (SE)

p-value

Beta (β)

Standard errors (SE)

p-value

Frontal

−0.31

0.004

0.002*

0.37

0.003

< 0.001*

Parietal

−0.50

0.003

< 0.001*

0.42

0.002

< 0.001*

Temporal

−0.11

0.004

0.314

0.22

0.003

0.032*

Occipital

−0.33

0.004

0.001*

0.25

0.003

0.014*

 

FDG

AV45

 

Beta (β)

Standard errors (SE)

p-value

Beta (β)

Standard errors (SE)

p-value

Frontal

−0.12

0.002

0.230

0.10

0.006

0.359

Parietal

0.00

0.002

0.965

0.22

0.006

0.034

Temporal

0.03

0.002

0.761

0.33

0.006

0.002*

Occipital

0.02

0.002

0.828

0.06

0.006

0.587

  1. Standardized Beta, standard errors (SE) and uncorrected p-value from regression linear models adjusted for age, gender, level of education and clinical status are indicated without correction for multiple analysis.
  2. * Significant after false discovery rate (FDR) correction for multiple analysis applied for each imaging modality (n = 4).
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