Table 4 Chromosomal copy number as assessed via bulk qPCR assay; five rounds of differentiation completed across two cell lines; One-way ANOVA performed comparing copy number against all loci; copy number < 1.5 or > 2.5 (< 0.7 or > 1.3 for chromosome X for lines from male donors) and p < 0.05 with post hoc Tukey adjustment indicate abnormality.

From: Examining iPSC derived motor neuron variability and genome stability monitoring as a solution

Cell Line

Differentiation Round

Detected Abnormalities

Copy Number

Adjusted p-value

Abnormal?

WTSli010-A

1,2

Chr1q

1.51

0.93

~

3,4

Chr8q, Chr17q, ChrXp

1.23, 1.17, 0.68

0.68, 0.64, 0.03

5

-

-

-

-

WTSli022-A

1,2

Chr18q

0.65

0.65

~

3,4

-

-

-

-

5

Chr18q

1.38

0.26

~