Fig. 10

Identification of candidate therapeutic agents and targets among the CS subgroups. (A) Venn diagram showing the included compounds from the CTRP and PRISM datasets. (B) Strategy diagram for identifying candidate agents with higher drug sensitivity in each CS subgroup. (C) Single-cell clustering of pan-cancer data based on drug sensitivity from the CTRP and PRISM datasets. (D) Spearman’s correlation analysis of CTRP-derived and PRISM-derived compounds among the CS subgroups. (E) Differential drug response analysis of CTRP-derived and PRISM-derived compounds among the CS subgroups. Lower AUC values indicated greater drug sensitivity. (F) Volcano plots (left panel) and scatter plots (right panel) of Spearman’s correlation coefficients and significance between CS-related cancer driver gene scores and CERES scores of drug targets in the CS subgroups. Color dots indicated targets with significant negative correlations (P < 0.05).