Fig. 2
Pan-cancer characterization of the CS subgroups in the tumor microenvironment. (A) Identification of gene expression signature modules and classification of the CS subgroups. Top panel: consensus clustering analysis based on CS-related gene expression signatures (rows and columns), which indicated five modules of shared correlations. Middle panel: representative signatures from each module (columns) were used to cluster cancer samples (rows). Bottom panel: distribution of signature scores among the five CS subgroups C1–C5 (rows), with dotted lines representing the median. (B) Differential expression of signaling pathways among the CS subgroups. (C) Circle heatmap showing the distribution of the CS subgroups in each cancer type. The subgroup proportion, cancer types, and tissue types were displayed from the outer to the inner side. (D) Distribution of cancer types in the CS subgroups. Bar charts reflected the proportion of each cancer type within each CS subgroup. (E) Distribution of the CS subgroups in different types of cancer and tissue. (F) Average CS scores of different cancer types (top panel) and tissue types (bottom panel). (G) Schematic description of differential features among the CS subgroups.
