Table 1 DOE as suggested by RSM for the desired composition.

From: Advanced optimization of dopant profiles in bismuth-enhanced bioactive glass through response surface methodology

Run

1

2

3

4

5

6

7

8

9

10

11

12

13

Bi Composition in wt%

3

3

6

3

0

3

0

3

6

3

7.2

3

− 1.2

Ca Composition in wt%

37

37

40

37

40

37

34

41.2

34

37

37

32.7

37

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