Fig. 2 | Scientific Reports

Fig. 2

From: α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages

Fig. 2

The anti-inflammatory effect of GTS-21 was attenuated by splenectomy. (A) Experimental design: Five days prior to LPS injection, splenectomy was conducted (n = 6 in each group). (B) The reduction in plasma TNF-α by GTS-21 was attenuated in splenectomized mice (LPS-vehicle-sham and LPS-GTS-21-sham; P = 0.0104, LPS-vehicle-SPLX and LPS-GTS-21-SPLX; P = 0.7935). The reduction rate of LPS-GTS-21, calculated in reference to the mean value of LPS-vehicle, has been included (LPS-vehicle-sham and LPS-GTS-21-sham; −30.9%, LPS-vehicle-SPLX and LPS-GTS-21-SPLX; −16.3%). Data are shown as mean ± SD. Statistical significance was assessed using two-way ANOVA analysis with Tukey’s multiple comparison. n.s., not significant, *P < 0.05.

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