Fig. 4 | Scientific Reports

Fig. 4

From: α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages

Fig. 4

RNA-seq revealed that Ccl2 was significantly altered by GTS-21 in both murine and human macrophages. (A, B) The Clustered heatmap shows selected genes with an absolute log2 fold change of LPS/CTL > 1 and LPS-GTS-21/LPS > 1 (350 genes in RAW 264.7 cells, 146 genes in U937 cells). (C) Venn diagram created by selecting genes with significant expression changes due to drug treatment in RAW 264.7 and U937 cells. The left side shows the selected genes in RAW 264.7 cells, while the right side shows the selected genes in U937 cells. There were 11 overlapping genes between RAW 264.7 and U937 cells. (D, E) Heatmaps showing transformed FPKM of 11 commonly selected genes in RAW264.7 (D) and U937 cells (E) among control, LPS, and LPS + GTS-21.

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