Fig. 4 | Scientific Reports

Fig. 4

From: Aggressive prolactinomas in men are associated with visual disturbances and pituitary hormone deficiencies

Fig. 4

Microscopic features of case 4. (A and B) Metastatic PitNET with nuclear pleomorphism, mitoses (hematoxilin and eosin). (C) Diffuse nuclear immunoreactivity for PIT1. (D) Cytoplasmic immunoreactivity for GH. (E) Cytoplasmic immunoreactivity for PRL. (F) Nuclear reactivity for estrogen receptor alpha. (G) The Ki67 labeling index is high (22%) (H) Strong immunohistochemical expression of p27. Original magnification: A, 200X; B, 400X; C-H, 200X.

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