Fig. 7
Effect of miR-5095 on tumor growth and metastasis in mouse models. (A) Representative images of tumors from xenograft mice (n = 5). (B) Changes in tumor volume.Statistical analysis was performed using a two-tailed paired t-test (P = 0.0006). (C) Changes in tumor weight. Statistical analysis was performed using a two-tailed paired t-test (P < 0.0001). (D) H&E staining to observe tissue morphology (scale bar = 100 μm). (E) Immunohistochemistry for Ki-67 expression (scale bar = 50 μm). Statistical analysis was performed using a two-tailed paired t-test (P = 0.0026). (F) H&E staining showing metastatic lesions in the lungs of mice (n = 3, scale bar = 200 μm). Statistical analysis was performed using a two-tailed paired t-test (P = 0.0008). *P < 0.05, **P < 0.01.
