Fig. 4 | Scientific Reports

Fig. 4

From: Effects of female hormone withdrawal and ulipristal acetate on MED12 mutation positive and negative uterine leiomyomas using a xenograft model

Fig. 4

Identification of differentially expressed genes (DEGs) in xenograft tumors by female hormone withdrawal and UPA administration. (A,B) Volcano plot showing the DEGs (red dots) identified in the E(-)P(-), E(+)P(-), and EP + UPA groups compared with the E(+)P(+) group in MED12m(+)-ULM (n = 3) (A) and MED12m(-)-ULM (n = 3) (B). DEGs were defined as the genes whose expression was more than 2-fold or less than 0.5-fold of that of the E(+)P(+) group in each group, and p-value < 0.05, (t-test). The number of the upregulated (Up) and downregulated (Down) DEGs are shown.

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