Table 1 Basic information on the ULM specimens used for the xenograft models in this study.
ULM ID | MED12 mutation | Age | Major axis x Minor axis (mm x mm) | Type | Single (S) | Surgical method | Collagen fiber ratio (%) | SMC ratio (%) | |
|---|---|---|---|---|---|---|---|---|---|
Multiple (M) | |||||||||
MED12m(+)-ULM | |||||||||
ULM#11 | c.131G> A, p.G44D | 27 | 64 × 62 | Subserous | S | LM | 46.7 | 56.6 | |
ULM#14 | c.131G> A, p.G44D | 49 | 35 × 30 | Subserous | M | TLH | 47.8 | 50.6 | |
ULM#15 | c.131G> C, p.G44A | 36 | 75 × 64 | Intramural | M | LM | 48.1 | 51.0 | |
ULM#16 | c.131G> A, p.G44D | 30 | 37 × 28 | Subserous | M | LM | 40.8 | 41.2 | |
ULM#18 | c.131G> T, p.G44V | 30 | 42 × 38 | Submucosal | M | LM | 49.7 | 69.0 | |
ULM#22 | c.131G> T, p.G44V | 43 | 144 × 96 | Intramural | M | TLH | 46.0 | 68.6 | |
ULM#27 | c.131G> T, p.G44V | 34 | 74 × 68 | Intramural | M | LM | 52.5 | 72.8 | |
ULM#29 | c.131G> T, p.G44V | 45 | 35 × 35 | Intramural | M | TLH | 45.9 | 75.6 | |
ULM#30 | IVS1-11_131del43 | 41 | ND | Intramural | M | LM | 42.4 | 67.5 | |
ULM#39 | c.130G> A, p.G44S | 49 | 42 × 36 | Intramural | M | AT | 56.9 | 62.7 | |
ULM#40 | c.131G> A, p.G44D | 39 | 28 × 23 | Intramural | M | LM | 43.1 | 54.0 | |
Mean ± SD | 38.5 ± 7.7 | 58 × 48 | 47.3 ± 4.6 | 60.9 ± 10.9 | |||||
MED12m(-)-ULM | |||||||||
ULM#12 | - | 47 | 29 × 23 | Intramural | M | TLH | 29.6 | 82.2 | |
ULM#13 | - | 40 | 83 × 35 | Intramural | S | TLH | 46.6 | 81.0 | |
ULM#19 | - | 47 | 80 × 69 | Intramural | M | TLH | 12.6 | 81.6 | |
ULM#20 | - | 42 | 81 × 74 | Intramural | S | TLH | 36.8 | 75.4 | |
ULM#24 | - | 41 | 50 × 50 | Submucosal | S | TLH | 32.2 | 84.4 | |
ULM#25 | - | 49 | 115 × 62 | Intramural | M | TLH | 49.6 | 75.5 | |
ULM#26 | - | 46 | 45 × 39 | Submucosal | S | TLH | 20.5 | 81.8 | |
ULM#31 | - | 37 | 52 × 52 | Intramural | M | LH | 23.6 | 86.4 | |
ULM#37 | - | 46 | 71 × 70 | Submucosal | S | RAH | 22.1 | 87.1 | |
ULM#38 | - | 49 | 37 × 26 | Intramural | S | TLH | 20.5 | 81.8 | |
ULM#46 | - | 44 | 60 × 50 | Intramural | S | RAH | 21.8 | 87.1 | |
Mean ± SD | 44.4 ± 3.9 | 64 × 50 | 28.7 ± 11.6 | 82.2 ± 4.0 | |||||
