Table 1 Baseline demographics, screening laboratories, and pulmonary function testing in long COVID subjects. *p < 0.05 comparing values before and after training.

From: Serum extracellular vesicle RNA profiles in long COVID: insights from exercise-induced gene modulation

Demographics

Results pre-training

Results post-training

Age (y)

53.5 ± 11.6

 

% female (n, %)

6 (43%)

 

BMI (kg/m2)

32.5 ± 8.4

 

Time since initial COVID infection (months)

15.1 ± 8.8

 

Primary Long COVID Symptom (n, %)

Fatigue (12/ 86%)

 
 

Dyspnea (5/ 36%)

 
 

Exercise Intolerance (6/46%)

 
 

Post Exertional Malaise (8/57%)

 
 

Brain Fog (14/100%)

 

Hemoglobin Range (Male 13.2–17)

14.9 ± 1.1

 

Hemoglobin Range (Female 11.7–15.5)

13.4 ± 0.9

 

Hematocrit Range (Male 38.5–50%)

44.1% ± 3.0

 

Hematocrit Range (Female 35–45%)

39.3% ± 2.6

 

CRP (normal < 8.0 ng/ml)

4.3 ± 5.8

 

High Sensitivity Troponin (normal < 15 ng/L)

6.8 ± 2.2

 

Pro-BNP (normal < 253 ng/L)

6.8 ± 2.2

 

Pulmonary Function Testing

  

FEV1% Predicted

94 ± 19

97 ± 17

TLC % Predicted

86 ± 12

89.69 ± 13.2

DLCO % Predicted

93 ± 18

91.77 ± 18.8

Exercise Testing and Training Outcomes

  

VO2, Absolute (L/min)

1.88 ± 0.69

2.03 ± 0.07*

VO2 ml/kg/min)

19.3 ± 5.1

20.9 ± 5.1*

VO2 (% predicted)

87% ± 17

93 ± 17

VO2 (% change) from Pre- to Post training

 

7.4%

Peak Work Rate; % predicted

93% ± 17

 

Peak Work Rate; Watts

139 ± 49

155 ± 55*

Peak Work Rate; % change from Pre- to Post-training

 

16%