Fig. 1 | Scientific Reports

Fig. 1

From: Comprehensive analysis of ALYREF gene expression and its correlation with immunotherapy efficacy and circulating tumor cells in bladder cancer

Fig. 1

ALYREF Pan-Cancer Expression Analysis: (A) Box plot representation of ALYREF expression levels comparing tumor tissues to corresponding normal tissues across various cancer types in the TCGA dataset. Statistical significance was determined using Wilcoxon Rank Sum Tests (p < 0.05). The plot illustrates a predominant increase in ALYREF expression in tumor samples compared to their normal counterparts. (B) Extended box plots integrating TPM expression levels from GTEx normal samples with TCGA tumor samples, emphasizing the contrast in ALYREF expression between a larger cohort of normal tissues and tumor tissues. (C) Box plots of paired comparisons within the TCGA cohort, showing ALYREF expression in tumor tissues versus adjacent normal tissues. The plots indicate a consistent pattern of higher ALYREF expression in the majority of tumor tissues when directly compared to their adjacent normal samples. (D) Immunohistochemical analysis from the HPA database depicting ALYREF protein levels across various tumors. The images confirm the mRNA expression results, showing increased ALYREF protein abundance in tumor tissues.

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