Table 3 Spectrum of activity testing from diet bioassays with the Vip3Cb1 protein on target lepidopteran and non-lepidopteran insect species.

From: Characterization of the spectrum of insecticidal activity of Cry1B.3, Cry1Da_7, and Vip3Cb1 proteins produced by lepidopteran-protected MON 89151 cotton

Common name (insect code)

Mean EC50 (95% CI) or maximum concentration tested (µg/mL diet)

Activity on survival

Activity on growth6

Fall armyworm (FAW)

0.054 (0.032–0.090)

N/A5

N/A

Corn earworm (CEW)

0.20 (0.15–0.28)

N/A

N/A

European corn borer (ECB)

0.28 (0.19–0.42)

N/A

N/A

Tobacco budworm (TBW)

0.14 (0.11–0.18)

N/A

N/A

Colorado potato beetle (CPB)

170.52

No

No

Southern corn rootworm (SCR)

141.72

No

No

Western corn rootworm (WCR)

2501

No

No

Mexican bean beetle (MBB)

250

No

Yes3

Neotropical brown stink bug (NBS)

2501

No

N/A

Western tarnished plant bug (WTP)

2501

No

N/A

Common fruit fly (CFF)

250

Yes4

No

  1. 1The highest concentration tested which showed no effect.
  2. 2Adjusted concentration based on protein stability in diet, and time-weighted mean35 (Table S5), which showed no effect (Table S6).
  3. 3A statistically significant body mass effect was observed for MBB at 250 µg Vip3Cb1/mL diet. No effect on body mass was observed at 100 µg Vip3Cb1/mL diet and no effect on survival was observed at 100 or 250 µg Vip3Cb1/mL diet.
  4. 4A statistically significant survival effect was observed for CFF at 250 µg Vip3Cb1/mL diet. No effect on survival was observed at 50 or 100 µg Vip3Cb1/mL diet and no effect on development time to pupa was observed at 50, 100 or 250 µg Vip3Cb1/mL diet.
  5. 5N/A = not applicable.
  6. 6Body mass for CPB, SCR, WCR and MBB. Development time to pupa for CFF.
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